Proteomics

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Label-free quantitative proteomic analysis for normal and inflamed colonic mucosa from patients with ulcerative colitis

ABSTRACT: Label-free quantitative proteomic analysis for clinical tissues of 5 normal and 5 inflamed colonic mucosa. The EASY-nLC 1200 system and Q Exactive Plus were used for peptides detection. A total of 4102 proteins were identified, and 2713 proteins were quantified. According to the criterion fold change > 2 and adjusted P value less than 0.05, we found 159 differential protein.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wei Zhou  

PROVIDER: PXD061745 | iProX | Wed Mar 12 00:00:00 GMT 2025

REPOSITORIES: iProX

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To date, treating ulcerative colitis (UC) remains a significant challenge due to its complex etiology. In this study, metabolomics and proteomics analysis for multi-center cohorts reveal that both serum arginine levels and the rate-limiting enzyme argininosuccinate synthetase 1 (ASS1) are significantly elevated in UC patients. Exogenous arginine infusion and ASS1 overexpression exacerbate the pathological features of colitis in mice, while inhibiting or silencing ASS1 offers protection against e  ...[more]

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