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Targeting Lipid raft-related stomatin strategy for challenging osteoporosis

ABSTRACT: Mouse bone marrow macrophages, with or without the addition of RANKL, are being investigated for their interactions with proteins that associate with the stomatin protein.

ORGANISM(S): Mus Musculus

SUBMITTER: Dechun Geng

PROVIDER: PXD061779 | iProX | Thu Mar 13 00:00:00 GMT 2025

REPOSITORIES: iProX

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Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models.

Tao Huaqiang H Chen Kai K Wang Qiufei Q Zhu Pengfei P Chu Miao M Chen Wenxiang W Yang Chen C Gu Ye Y Yang Huilin H Zhou Qi Q Lv Shujun S Geng Dechun D

Nature communications 20250701 1

Osteoporosis is a metabolic bone disease characterized by a disruption in the balance between bone resorption and formation. The specific role and mechanism of stomatin (STOM), a major component of lipid rafts, in regulating bone physiology remain unclear. This research identifies increased STOM expression in bone tissue of osteoporosis patients and ovariectomized mice. STOM-deficient mice show higher bone mass under both normal conditions and after ovariectomy. Furthermore, we clarify that STOM ...[more]

PMID: 40595453

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