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Proteomic study of exfoliation syndrome

ABSTRACT: We provided a comprehensive plasma proteome analysis and expanded the profile of human plasma proteome. The differential plasma proteomic analysis of age-related cataract and exfoliation syndrome with/without glaucoma indicated that plasma proteome can reflect the pathophysiological situation of diseases.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xinbo Gao

PROVIDER: PXD061945 | iProX | Mon Mar 17 00:00:00 GMT 2025

REPOSITORIES: iProX

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Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker.

Li Jiayong J Ma Yuncheng Y Xie Lingling L Zhuo Kaichen K He Yuxian Y Ma Xin X Zheng Shufen S Guo Shicheng S Tang Yizhen Y Muhetaer Guzainuer G Aizezi Mireayi M Zhang Dan D Wumaier Aizezi A Zhang Xu X Tang Chao C Wang Wei W Huang Wenyong W Gao Xinbo X

Investigative ophthalmology & visual science 20250301 3

<h4>Purpose</h4>This study investigated the proteomic landscape of exfoliation glaucoma to find potential biomarkers.<h4>Methods</h4>The study enrolled 34 patients diagnosed with either exfoliation syndrome with/without glaucoma or age-related cataract. Plasma proteins were analyzed through mass spectrometry and Mendelian randomization (MR) based on data from deCODE, FinnGen, Atherosclerosis Risk in Communities (ARIC), eQTLGen, and UK Biobank (UKB) cohorts to infer relationships.<h4>Results</h4> ...[more]

PMID: 40052860

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