Proteomics

Dataset Information

0

Identification of Per2-associated proteins in oral squamous carcinoma cell using LC-MS/MS

ABSTRACT: To identify potential proteins interacting with Per2 in oral squamous carcinoma cells, we performed SDS-PAGE followed by LC-MS/MS analysis of FLAG-Per2 immunoprecipitated proteins in cell extracts from SCC25 cells transfected with the FLAG-Per2 plasmid.

ORGANISM(S): Homo Sapiens

SUBMITTER: Kai Yang  

PROVIDER: PXD062046 | iProX | Wed Mar 19 00:00:00 GMT 2025

REPOSITORIES: iProX

Json Xml
altmetric image

Publications

PER2 interaction with HSP70 promotes cuproptosis in oral squamous carcinoma cells by decreasing AKT stability.

Yu Wenguang W   Yin Shilin S   Tang Hong H   Li Hengyan H   Zhang Zhiwei Z   Yang Kai K  

Cell death & disease 20250320 1

Oral squamous cell carcinoma (OSCC) has a poor prognosis, with unclear mechanisms posing a challenge for the development of effective treatment strategies. Cuproptosis is a novel cell death mode that disrupts mitochondrial metabolism. Clarifying the mechanisms that regulate cuproptosis may provide important new insights to guide OSCC treatment. Here, we found that the biological clock gene Period2 (PER2) was under-expressed in OSCC, with consequent inhibition of cellular cuproptosis, whereas it  ...[more]

Similar Datasets

Genomics Canine oral squamous cell carcinoma
2024-06-30 | PRJEB77007 | EVA
Transcriptomics Expression data from fibroblasts derived from human normal oral mucosa, oral dysplasia and oral squamous cell carcinoma
2013-12-01 | E-GEOD-38517 | biostudies-arrayexpress
Transcriptomics Affymetrix SNP array data for oral squamous cell carcinoma and oral dysplasia samples
2013-10-22 | E-GEOD-51265 | biostudies-arrayexpress
Methylation profiling Epigenome analysis of normal oral keratinocytes cells and oral squamous cell carcinoma (OSCC) cells
2024-05-29 | GSE262310 | GEO
Transcriptomics Expression data from fibroblasts derived from human normal oral mucosa, oral dysplasia and oral squamous cell carcinoma
2013-12-01 | GSE38517 | GEO
Transcriptomics RNA-Seq of oral squamous cell carcinomas and matched normal tissues
2010-02-25 | E-GEOD-20116 | biostudies-arrayexpress
Transcriptomics Apolipoprotein E promotes invasion in oral squamous cell carcinoma
2016-04-01 | GSE79795 | GEO
Transcriptomics Gene expression profiles in human oral squamous cell carcinoma tissues and cell lines
2012-09-30 | E-GEOD-36090 | biostudies-arrayexpress
Proteomics Identification of CMTM6 as a novel mediator of cisplatin resistance in oral squamous cell carcinoma
2020-01-07 | MSV000084761 | MassIVE
Proteomics NRF2 activation in TRP53:P16 deficient mice drives oral squamous cell carcinoma
2024-01-31 | PXD048887 | Pride