Human VSMC infected with Ad-CEMIP and immunoprecipitated with anti-CEMIP for proteomic analysis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Yi Zhu
PROVIDER: PXD062060 | iProX | Thu Mar 20 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
CEMIP Maintains Vascular Contractility by Controlling PP1c-MLC20 Cascade in SMCs.
Yuan Ze Z Li Qi Q Bai Xue X Zhang Kai K He Jinlong J Ai Ding D Cui Qinghua Q Zhu Yi Y Li Bochuan B
Circulation research 20250701 4
<h4>Background</h4>The CEMIP (cell migration-inducing protein) exhibits extremely high expression levels in smooth muscle tissues. However, whether CEMIP modulates the contractile phenotype of vascular smooth muscle cells and confers blood pressure remains elusive.<h4>Methods</h4>To explore the role of CEMIP in SMCs, we generated a mouse model with SMC-specific CEMIP deficiency (SMC-<i>Cemip</i><sup><i>KO</i></sup>). By combining coimmunoprecipitation assay and molecular docking prediction, we i ...[more]
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