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Proteogenomic landscape of the Esophageal Squamous Cell Cancer reveals the lipid droplet formation process as a novel therapeutic target

ABSTRACT: The integrated proteogenomic analysis revealed proteomic characteristics associated with genomic variants and clinical features including arm or focal amplifications, SNV mutations, tumor size, lymph node metastasis, smoking history.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chen Ding

PROVIDER: PXD062163 | iProX | Mon Mar 24 00:00:00 GMT 2025

REPOSITORIES: iProX

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Proteogenomic characterization reveals that lipid droplet formation promotes esophageal squamous cell cancer progression.

Qin Zhaoyu Z Jiang Dongxian D Yu Zihan Z Li Lingling L Xu Wenhao W Xu Chen C Song Qi Q Sun Xiaogang X Li Liangyuan L Guo Wenjia W Pu Yan Y Feng Jinwen J Liu Yang Y Wang Haixing H Wang Lan L Qu Yuanyuan Y He Fuchu F Qin Jun J Tan Lijie L Zhao Jian-Yuan JY Yang Wenjun W Hou Yingyong Y Ding Chen C

Science translational medicine 20250611 802

Esophageal cancer is one of the most common cancers and a leading cause of cancer-related mortality in the world. Here, we have performed comprehensive characterization of genetic, transcriptomic, proteomic, and phosphoproteomic features in 293 patients with esophageal squamous cell carcinoma (ESCC). Chromosome 12q13.13 amplification was correlated with the up-regulation of Janus kinase-signal transducer and activator of transcription pathway and keratins at the protein level in ESCC tissues and ...[more]

PMID: 40498854

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