Proteomics

Dataset Information

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Molecular Landscape of Atherosclerotic Plaque Progression: Insights from Proteomics

ABSTRACT: This dataset comprises proteomic profiles of 87 human carotid atherosclerotic plaques from patients undergoing carotid endarterectomy (CEA). The study employed an integrated approach using Data Independent Acquisition (DIA) proteomics. A total of 87 human carotid plaques were analyzed to identify and quantify protein expression. The proteomic analysis of the 87 carotid plaques revealed 6143 proteins, highlighting diverse expression profiles across different plaque stages.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wei Sun  

PROVIDER: PXD062283 | iProX | Wed Mar 26 00:00:00 GMT 2025

REPOSITORIES: iProX

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Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics.

Wang Chaonan C   Feng Yuyao Y   Liu Xiaoyan X   Sun Haidan H   Guo Zhengguang Z   Shao Jiang J   Li Kang K   Chen Junye J   Shu Keqiang K   Kong Deqiang D   Wang Jiaxian J   Li Yiran Y   Lei Xiangling X   Li Chen C   Liu Bao B   Sun Wei W   Lai Zhichao Z  

BMC medicine 20250501 1

<h4>Backgrounds</h4>Atherosclerosis is a major contributor to cardiovascular diseases worldwide. Despite advancements in understanding its pathology, significant gaps remain in the molecular characterization of atherosclerotic plaques. This study addresses this gap by extensively profiling the proteomic landscape of carotid atherosclerotic plaques, classified under the American Heart Association (AHA) types IV to VI, to identify potential biomarkers and therapeutic targets.<h4>Methods</h4>The st  ...[more]

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