Dataset Information
Proteomic profiling of the global protein changes of Neuro-2a cells treated with siFUS or control
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Songbo Xie
PROVIDER: PXD062670 | iProX | Mon Apr 07 00:00:00 GMT+01:00 2025
REPOSITORIES: iProX
Publications
DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases.
Nature communications 20250520 1
Oligonucleotide-based medicine faces challenges in efficiently crossing the blood-brain barrier and rapidly reducing toxic proteins. To address these challenges, here we establish an integrated modality, brain-penetrant DNA nanoflowers incorporated with oligonucleotide-based proteolysis targeting chimeras. Using FUS as a proof-of-concept, mutations of which cause frontotemporal dementia and amyotrophic lateral sclerosis, we demonstrate that a FUS-engaging RNA oligonucleotide crosslinked to a lig ...[more]
