Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

With the introduction of nanoplastics, the physiological distinctions between PFOA and its substitute GenX on two types of freshwater algae became less pronounced.

ABSTRACT: Nanoplastics will carry PFAs, achieving "secondary transport", which in turn affects more metabolic processes, especially the enzymes of the translation system. This ultimately increased the physiological damage and growth inhibition of PFAs on algal cells, reduced the difference in physiological effects of different types of PFAs on algal cells, and increased the risk of GenX.

ORGANISM(S): Microcystis Aeruginosa Chlorella Virus

SUBMITTER: Ruikai Li

PROVIDER: PXD063089 | iProX | Thu Apr 17 00:00:00 GMT+01:00 2025

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Similar Datasets

With the introduction of nanoplastics, the physiological distinctions between PFOA and its substitute GenX on two types of freshwater algae became less pronounced.

Project description:With the introduction of nanoplastics, the physiological distinctions between PFOA and its substitute GenX on two types of freshwater algae became less pronounced.

| PRJEB88561 | ENA

Nanoplastics Enhance Transmembrane Transport of Carcinogens and Induce Cellular Stress Responses as Revealed by mRNA Sequencing Analysis

Project description:Nanoplastics were generated from common consumer plastics (PET, HDPE, PS, PVC) and exposed to simulated marine weathering for up to 10 weeks. Fourier-Transform Infrared (FT-IR) spectroscopy and ζ-potentials measurements revealed continuous changes in the composition of the nanoplastics consistent with oxidation. Although the chemical composition and oxidation of the nanoplastics influenced their ability to sorb Polycyclic Aromatic Hydrocarbons (PAHs), for all investigated conditions, sorption of PAH to nanoplastics achieved effective PAH concentrations that were orders of magnitude higher than the solubility limit in water. In an intestinal membrane model, PAH-loaded nanoplastics enhanced the overall PAH transport into and across the membrane, with HDPE achieving the highest intracellular PAH concentration. RNA sequencing of cell membranes exposed to nanoplastics revealed significant transcriptional changes, including upregulation of oxidative stress and detoxification pathways (NQO1, CYP1A1, CYP1B), especially in response to PAH-loaded nanoplastics, while genes associated with basic cell functions, such as cellular migration (NCKAP5, MACROD2) and division (KIF20A) were downregulated. These findings suggest that nanoplastics can increase bioaccessibility and bioavailability of hydrophobic carcinogens and enhance cellular stress, raising concerns about the potential environmental and health impacts associated with nanoplastics as carriers of hydrophobic environmental toxins.

2025-06-20 | GSE281152 | GEO

Nanoplastics-16s

Project description:Nanoplastics-16s Raw sequence reads

| PRJNA948176 | ENA

RNA-seq of leaves of two durum wheat lines in response to polystyrene nanoplastics (PSNPs) exposure

Project description:The increasing presence of nanoplastics in agricultural soils, particularly polystyrene nanoplastics (PSNPs), poses a novel and underestimated threat to crop productivity and food security. The impact of plastics has recently been investigated in cereals confirming that PSNPs can be absorbed by plants through the roots and subsequently translocated to other plant organs. While extensive research has focused on bread wheat, the effects of PSNPs on durum wheat (Triticum turgidum ssp. durum) remain largely unexplored. In this study, we examined the transcriptomic response to PSNPs exposure in two durum wheat lines: Kronos (wild type) and MRP3, a low-phytate mutant generated via TILLING. The MRP3 line carries deleterious mutation in the Multidrug Resistance-Associated Protein 3 (MRP3) genes, which encodes a vacuolar transporter of phytic acid.

2026-06-25 | E-MTAB-15975 | biostudies-arrayexpress

Gut-Lung Microbiota Dynamics in Mice Exposed to Nanoplastics

Project description:The objective was to evaluate the impact of nanoplastics on various niches of the microbiome in a mouse model

2024-10-21 | GSE265766 | GEO

Oral ingestion of polystyrene nanoplastics causes memory impairment and neuroinflammation by microglial uptake

Project description:Nanoplastics are produced by breakdown of plastics in environmental contamination or commercial use for cosmetics or daily expenses. Emerging evidence indicate that ingested nanoplastics with a size smaller than 100 nm have the potential to reach the brain and induces neurotoxicity. However, the potential toxicity of nanoplastics on brain are limited because of difficulties in synthesize of nanoplastics. In present study, we synthesized the fluorescent polystyrene nanoplastics (PSNPs) and examined the toxicity of PSNPs in brain in vivo and in vitro analyses by comparison to IR-813 fluorophore. Synthesized PSNPs were characterized by fluorescence imaging system, scanning electron microscopy, and Fourier-transform infrared spectroscopy. PSNPs were detected in adult mice brain by oral ingestion. In addition, a series of behavioral analyses showed that oral ingestion of PSNPs induced memory impairments. Among brain cells, PSNPs were predominantly internalized in microglia, and uptake of PSNPs induced microglial activation. In addition, the conditioned medium derived from microglia exposed to PSNPs repressed hippocampal neuronal activity. Furthermore, transcriptome analysis showed that PSNPs changed gene expressions in microglia, elevation of neuroinflammation in contrast to suppression of neurotrophic factors. These results indicated that predominant uptake of PSNPs in microglia induced elevation of neuroninflammatory responses whereas suppression of neurotrophic factors that may contribute to the cognitive impairment. Our findings indicate the toxic mechanism and potential detrimental effect of nanoplastic in brain and suggest a potential risk of cognitive impairment by exposure to nanoplastics.

2023-09-24 | GSE243612 | GEO

Aberrant Cell Fate and Functional Impairment in Developing Human Liver Organoids Exposed to Nanoplastics

Project description:Nanoplastics represent an emerging class of global environmental contaminants; however, their potential to interfere with human developmental processes remains largely unexplored. This study investigated the impact of exposure to polystyrene nanoplastics (PS-NP) on the de novo formation, differentiation, and function of human liver organoids derived from induced pluripotent stem cells (hiPSCs), a sophisticated model of early organogenesis.

2025-12-01 | GSE298927 | GEO

Single-cell transcriptome profile of mouse gallbladder cells after nanoplastics exposure

Project description:To understand molecular events of gallbladder cells during nanoplastics exposure, we performed scRNA-seq on gallbladder using 10x Genomics Chromium platform

2025-01-01 | GSE254778 | GEO

Nanoplastics Elicit Stage-Specific Physiological, Biochemical, and Gut Microbiome Responses in a Freshwater Mussel.

Project description: Not available

| S-EPMC12115734 | biostudies-literature

Differentially forms of nitrogen regulates the response of Microcystis aeruginosa to nanoplastics under environmentally relevant nitrogen concentration

Project description:As an essential primary producer, cyanobacteria play an important role in the global cycle for both carbon and nitrogen in the ecosystems. Though the influence of nanoplastics on the carbon metabolism of cyanobacteria, especial Microcystis aeruginosa, a dominant species causing cyanobacterial blooms, is well studied, little is known about nanoplastics affecting the nitrogen metabolism.

2023-09-01 | GSE214536 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data