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Global chromatin-associated O-GlcNAc proteins are biased to oncogene-induced senescence (OIS) in human primary fibroblasts

ABSTRACT: O-linked β-N-acetylglucosamine (O-GlcNAc) modification, a posttranslational modification (PTM) enriched in the nucleus and cytoplasm, is acknowledged to substantially contribute to the regulation of chromatin assembly and gene expression. studies have indicated that O-GlcNAc modification plays an important role in the process of cellular senescence. To integratively illustrate the regulatory role of O-GlcNAc modification in the oncogene-induced senescence (OIS) process, we employed a chemical reporter-based multi-omics strategy for a time-series proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins (OCPs) in human primary fibroblasts

ORGANISM(S): Homo Sapiens

SUBMITTER: Yubo Liu

PROVIDER: PXD063140 | iProX | Sun Apr 20 00:00:00 BST 2025

REPOSITORIES: iProX

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