Dataset Information

Long term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats

ABSTRACT: Alcoholic fatty liver disease (AFLD) is a liver disease closely related to long-term alcohol consumption. Although it is known that liver microsomal cytochrome P450 enzyme (CYP450) plays a crucial role in metabolizing alcohol and various exogenous compounds, the specific mechanism by which alcohol affects the activity and expression of CYP450 enzyme is still not fully understood. In addition, existing research mainly focuses on the effects of short-term alcohol exposure, and the understanding of how long-term alcohol intake changes CYP450 enzyme function and expression is still insufficient. Therefore, this study aims to explore the effects of long-term alcohol intake on CYP450 enzyme activity through an AFLD rat model, fill the gap in existing research, reveal the specific effects and possible molecular mechanisms of long-term alcohol consumption on liver CYP450 enzyme activity and expression, and provide new insights for developing treatment strategies for AFLD.

ORGANISM(S): Mus Musculus

SUBMITTER: Jun Li

PROVIDER: PXD063375 | iProX | Sun Apr 27 00:00:00 BST 2025

REPOSITORIES: iProX

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Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets.

Zhu Qian Q Xie Xuefeng X Fang Ling L Huang Cheng C Li Jun J

Frontiers in chemistry 20250513

<h4>Introduction</h4>Alcoholic fatty liver disease (AFLD) is a common consequence of chronic alcohol consumption, characterized by lipid accumulation and oxidative stress in the liver. Cytochrome P450 (CYP450) enzymes play essential roles in metabolizing alcohol and other compounds. However, the specific long-term effects of alcohol on these enzymes remain unclear.<h4>Methods</h4>This study the examines influence of prolonged ethanol exposure on CYP450 activity and expression in AFLD using a rat ...[more]

PMID: 40433307

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Dataset Information

Long term effects of ethanol intake on the CYP450 enzyme system in the liver of AFLD rats

Publications

Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets.

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