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Disruption of Iron Homeostasis Sensitizes Pancreatic Cancer to Irreversible Electroporation

ABSTRACT: Quantitative proten expression in Panc-1 cells treated with MOF-Fe and a Ferritin Degrader

ORGANISM(S): Homo Sapiens

SUBMITTER: Jun Zhao

PROVIDER: PXD063472 | iProX | Wed Apr 30 00:00:00 BST 2025

REPOSITORIES: iProX

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Disruption of iron homeostasis sensitizes pancreatic cancer to irreversible electroporation.

Li Linrong L Su Shihao S Wang Zhishan Z Sun Shuguo S Wang Yugang Y Xu Hui H Long Xin X Yin Tao T Zhao Jun J

Nature communications 20260119

Irreversible electroporation (IRE) is an ablative treatment for pancreatic cancer. It utilizes high-intensity pulsed electric field (PEF) to eliminate cancer cells by irreversibly disrupting cell membranes. However, PEF intensity is distributed unevenly; and cancer cells may survive in regions where it falls below the threshold of complete ablation. We find that iron-base metal organic framework nanoparticles (MOF-Fe) sensitize pancreatic cancer cells to PEF by inducing iron overload and ferropt ...[more]

PMID: 41554743

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| S-EPMC7240092 | biostudies-literature

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