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Proteomic and phospho-proteomic raw data of Wilms tumor tissue and normal adjacent kidney tissue.

ABSTRACT: Proteomic and phospho-proteomic raw data of Wilms tumor tissue and normal adjacent kidney tissue from Wilms tumor patients.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhixiang Wu

PROVIDER: PXD063650 | iProX | Wed Apr 30 00:00:00 BST 2025

REPOSITORIES: iProX

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Integrative proteogenomic characterization of Wilms tumor.

Cheng Cheng C Zhang Li L Chang Xiaofeng X Chen Kai K He Tian T Shi Jia J Lv Fan F Pan Lijia L Wu Yangkun Y Cheng Qianqian Q Ren Dong D Guo Yongli Y Zhang Weiping W Wang Huanmin H Shi Tieliu T Li Jing J Ni Xin X Wu Yeming Y Jin Yaqiong Y Wu Zhixiang Z

Nature communications 20250819 1

Wilms tumor (WT), the most common pediatric renal malignancy, exhibits a relatively low mutational burden compared to adult cancers, which hinders the development of targeted therapies. To elucidate the molecular landscape of WT, we perform integrative proteomic, phosphoproteomic, transcriptomic, and whole-exome sequencing analyses of WT and normal kidney tissue adjacent to tumor. Our multi-omics approach uncovers prognostic genetic alterations, distinct molecular subgroups, immune microenvironm ...[more]

PMID: 40830093

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