Proteomics

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A Tissue-Specific Atlas of Mouse N-Glycoproteome

ABSTRACT: In this study, we employed StrucGP to generate the first high-resolution and site-specific N- glycoproteomic atlas across 24 diverse mouse tissues. This comprehensive dataset provides an unprecedented insight into the tissue-specific landscape of N-glycosylation, revealing how distinct glycan structures and site-specific modifications contribute to tissue identity and specialization.

ORGANISM(S): Mus Musculus

SUBMITTER: Shisheng Sun  

PROVIDER: PXD063701 | iProX | Wed May 07 00:00:00 BST 2025

REPOSITORIES: iProX

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Publications

A comprehensive N-glycoproteome atlas reveals tissue-specific glycan remodeling but non-random structural microheterogeneities.

Wu Yongqi Y   Yang Muyao M   Xu Yongchao Y   Jia Li L   Li Jun J   Wang Xiaohan X   Zhao Jiayu J   Cai Yinli Y   Zhang Yiwen Y   Sun Shisheng S  

Nature communications 20260113 1

The mouse is a key model in biomedical research, yet its tissue-specific glycoproteome remains incompletely characterized due to glycan complexity and microheterogeneity. Here, we present a comprehensive N-glycoproteomic atlas across 24 mouse tissues, comprising 3045 N-glycans with distinct structural features attached at 8681 glycosites on 74,277 glycopeptides and 5026 glycoproteins. Among these glycans, 2687 (88.2%) meet the high-confidence threshold through an integrative confidence-estimatio  ...[more]

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