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Systematic investigation into the dynamic alterations in the proteome and phosphoproteome of mycobacteria following overexpression of PknG

ABSTRACT: Systematic investigation into the dynamic alterations in the proteome and phosphoproteome of mycobacteria following overexpression of PknG

ORGANISM(S): Mycolicibacterium Smegmatis Mc2 51

SUBMITTER: Junyu Xu

PROVIDER: PXD063872 | iProX | Tue May 13 00:00:00 BST 2025

REPOSITORIES: iProX

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Characterization of the Biological Effect Mediated by Mycobacterial Kinase PknG on Protein Phosphorylation and Acetylation.

Xie Shuyu S Liu Tianqi T Zhang Luoxi L Yang Yang Y Tang Yanqing Y Ye Tong T Sun Yewen Y Li Yi Y Shen Shiyang S Tan Minjia M Xu Jun-Yu JY

ACS omega 20250521 21

Tuberculosis (TB) remains a significant global public health challenge, with post-translational modifications (PTMs) in mycobacteria being integral to physiological processes, pathogenesis, and drug resistance mechanisms. Protein kinase G (PknG), the only reported secreted kinase in mycobacteria, is associated with virulence, immune evasion, and drug resistance. Nevertheless, the comprehensive range of proteins and phosphorylation modifications regulated by PknG in mycobacteria has not yet been ...[more]

PMID: 40488057

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