Act1 disrupts SHP2 stability by shifting the pyroglutamylation-ubiquitination balance to inhibit tumor progression
Ontology highlight
ABSTRACT: SHP2 stability is regulated by the dynamic antagonism of pyroglutamylation and ubiquitination, with Act1 influencing this balance, impacting cancer progression and therapy.
ORGANISM(S): Homo Sapiens
SUBMITTER:
Qiong Luo
PROVIDER: PXD064284 | iProX | Fri May 23 00:00:00 BST 2025
REPOSITORIES: iProX
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