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UBE2T mediated HP1α ubiquitination enhances nucleolar function and promote the progression of IDH1/TP53-mutant glioma

ABSTRACT: High-grade glioma is the most aggressive form of primary brain tumor, characterized by rapid progression and a grim prognosis. The presence of mutations in the IDH1 and TP53 is associated with a specific molecular phenotype in glioma, and their interaction is a potential target for therapy.

ORGANISM(S): Homo Sapiens

SUBMITTER: Tianfu Yu

PROVIDER: PXD064431 | iProX | Fri May 30 00:00:00 BST 2025

REPOSITORIES: iProX

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