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Identification of MGF505-3R interacting proteins by LC-MS/MS

ABSTRACT: Co-immunoprecipitation assay was investigated and subjected to SDS-PAGE. The gels were stained by Coomassie Brilliant Blue G-250 and sent to Novogene (Beijing, China) for LC-MS/MS analysis to identified the potential interaction protein between MGF360-13L and host protein.

ORGANISM(S): Sus Scrofa Domesticus

SUBMITTER: Hanchuan Dai

PROVIDER: PXD064545 | iProX | Fri May 30 00:00:00 BST 2025

REPOSITORIES: iProX

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African swine fever virus MGF505-3R facilitates ferroptosis to restrict TBK1-IRF3 pathway.

Niu Sai S Zhou Ying Y Fang Chunyue C Yang Yonggen Y Wang Junjie J Gao Shandian S Dai Hanchuan H

Microbiology spectrum 20250623 8

African swine fever virus (ASFV) causes hemorrhagic, severe infectious diseases and serious economic losses to the pig industry. ASFV multigene family 505 can antagonize the host's innate immunity through multiple signaling pathways and is considered an important target for vaccine development. However, the mechanism by which it induces host cell damage remains unclear. In this study, we observed that ASFV infection, similar to RSL3, can induce ferroptosis with the accumulation of reactive oxyge ...[more]

PMID: 40548711

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