Multi-Omics Analysis Reveals RNA Polymerase II Degradation as a Novel Mechanism of PF-3758309's Anti-Tumor Activity

ABSTRACT: In this study, we conducted a comprehensive multi-omics analysis, including proteomics, transcriptomics, and ubiquitinomics, to investigate the mechanism of PF-3758309 in HCT116 cells. Our results revealed that PF-3758309 promotes the degradation of RNA polymerase II subunit proteins (POLR2A/B/E) via the cullin-RING ligase pathway.

ORGANISM(S): Homo Sapiens

SUBMITTER: Minjia Tan  

PROVIDER: PXD064705 | iProX | Thu Jun 05 00:00:00 GMT+01:00 2025

REPOSITORIES: iProX