Multi-omics single-cell atlas reveals kidney-infiltrating S100A8/A9-high neutrophils as pioneer cells driving fatal urosepsis

ABSTRACT: We developed a novel Sepsis-Related Death (SRD) rat model that replicates urosepsis progression. We performed multi-omics analysis (transcriptomics, proteomics, and metabolomics) on early septic kidney tissues, followed by comprehensive single-cell RNA sequencing of kidney tissues at different disease stages. We validated key findings using immunohistochemistry, immunofluorescence, large-scale public dataset integration, and analysis of clinical samples.

ORGANISM(S): Mus Musculus

SUBMITTER: Baoqing Sun  

PROVIDER: PXD064759 | iProX | Sun Jun 08 00:00:00 BST 2025

REPOSITORIES: iProX