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Quantitative phosphoproteomic analysis of overexpressing PPP1R12B and control Huh7 cells samples using 4D-SmartDIA

ABSTRACT: Quantitative phosphoproteomic analysis of overexpressing PPP1R12B and control Huh7 cells samples using 4D-SmartDIA.

ORGANISM(S): Homo Sapiens

SUBMITTER: Lei Chen

PROVIDER: PXD064803 | iProX | Tue Jun 10 00:00:00 BST 2025

REPOSITORIES: iProX

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PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma.

Zhang Yangqianwen Y Liu Shuowu S Bai Mixue M Zhao Zihan Z Wang Shan S Bao Meiyu M Bao Jinxia J Shen Siyun S Lu Shuang S Xiong Ying Y Gu Gaoxiang G Wang Hongyang H Chen Lei L

Frontiers in cell and developmental biology 20250619

Protein phosphatase 1 regulatory subunit 12B (PPP1R12B) is a regulatory subunit of protein phosphatase 1. While our previous study identified the inhibitory role of PPP1R12B in hepatocellular carcinoma (HCC), the precise molecular mechanisms underlying its anti-proliferative effects remain unclear. Herein, we demonstrated that PPP1R12B expression is significantly downregulated in HCC tissues and serves as an independent prognostic marker for favorable patient outcomes. Additionally, overexpressi ...[more]

PMID: 40612101

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