Multi-dimensional Proteomics Reveal Metformin's Impact on Interconnected Regulatory Networks of Protein Turnover, Ubiquitination, DNA Damage, and Cell Cycle

ABSTRACT: In this study, we investigated the impact of metformin on the cellular ubiquitinome and associated protein turnover. Through an integrated analysis combining ubiquitinome profiling with pulsed metabolic labeling, we found that metformin markedly suppresses global protein ubiquitination, including various types of ubiquitin chain linkages, and concurrently inhibits both protein synthesis and degradation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yaoyang Zhang  

PROVIDER: PXD065302 | iProX | Fri Sep 26 00:00:00 BST 2025

REPOSITORIES: iProX