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Alphavirus M1 disrupts super-enhancer-driven oncogenic transcription in osteosarcoma

ABSTRACT: This dataset includes tandem mass tag (TMT)-based quantitative proteomics and immunoprecipitation-mass spectrometry (IP-MS) data derived from osteosarcoma cells infected with the oncolytic M1 virus. The proteomic analysis was performed to identify differential protein expression, focusing on changes in super-enhancer-associated transcriptional regulators, particularly RNA polymerase II subunit RPB1. The IP-MS dataset captures interacting proteins of RPB1 and viral non-structural protein NSP2, aiming to uncover the mechanism by which NSP2 mediates CUL2 E3 ligase complex recruitment and promotes RPB1 ubiquitination and degradation. These data support the mechanistic findings presented in the manuscript titled “Alphavirus M1 disrupts super-enhancer-driven oncogenic transcription via non-structural protein NSP2 in osteosarcoma.“

ORGANISM(S): Homo Sapiens

SUBMITTER: Jingnan Shen

PROVIDER: PXD065368 | iProX | Mon Jun 23 00:00:00 BST 2025

REPOSITORIES: iProX

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