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Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency

ABSTRACT: In this study, EVs were extracted and purified from the culture medium of adipose-derived mesenchymal stem cells isolated from rats. A total of three batches of extracellular vesicles were obtained from the cell samples for the exploration of potential vital protein components in ADSCs and ADSC-EVs.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Wen Li

PROVIDER: PXD065879 | iProX | Tue Jul 08 00:00:00 BST 2025

REPOSITORIES: iProX

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Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency.

Li Yanquan Y Chen Feng F Zhao Wei W Sun Di D Zhang Li L Qiao Rui R Hu Qianhui Q Li Songmao S Chen Boyuan B Ding Haixia H Zhang Meiling M Zhang Qing Q Guo Fanghao F Li Wen W

Stem cell research & therapy 20250805 1

<h4>Background</h4>Premature ovarian insufficiency (POI) is a challenging condition with limited effective treatments. Adipose-derived stem cells (ADSCs) have demonstrated potential in tissue repair, and their extracellular vesicles (ADSC-EVs) show more safety in clinical translation. However, the role and mechanism of ADSC-EVs in the treatment of POI are not yet fully understood. This study aims to investigate the protective effects of ADSC-EVs on rat POI models induced by 4-vinylcyclohexene di ...[more]

PMID: 40765000

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