Proteomics

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Lysosome-targeting chimeras based on retinoic acid modification for cancer therapy


ABSTRACT: We developed retinoic acid-based LYTACs (RATACs) to overcome synthesis and druggability issues. RATACs degrade EGFR, PD-L1, TGF-β, and IgG, showing superior anti-tumor effects in liver and lung cancer models compared to conventional antibodies.

ORGANISM(S): Homo Sapiens

SUBMITTER: Longguang Tang  

PROVIDER: PXD066144 | iProX | Mon Jul 14 00:00:00 BST 2025

REPOSITORIES: iProX

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