Lysosome-targeting chimeras based on retinoic acid modification for cancer therapy
Ontology highlight
ABSTRACT: We developed retinoic acid-based LYTACs (RATACs) to overcome synthesis and druggability issues. RATACs degrade EGFR, PD-L1, TGF-β, and IgG, showing superior anti-tumor effects in liver and lung cancer models compared to conventional antibodies.
ORGANISM(S): Homo Sapiens
SUBMITTER:
Longguang Tang
PROVIDER: PXD066144 | iProX | Mon Jul 14 00:00:00 BST 2025
REPOSITORIES: iProX
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