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Identification of Tim-4 Binding Proteins in Peritoneal Macrophages

ABSTRACT: T-cell immunoglobulin and mucin domain containing 4 (Tim-4) is known to suppress macrophage inflammatory responses in various diseases, but its role and underlying mechanism in peritoneal macrophage (PEMs) with LPS stimulation are unknown. PEMs were isolated from Tim-4fl/fl mice and LysM-Cre; Tim-4fl/fl mice, followed by stimulation with 100 ng/mL LPS for 24 hours. After validating the successful knockout of Tim-4 in macrophages, mass spectrometry was employed to identify differentially expressed proteins in PEMs.

ORGANISM(S): Mus Musculus

SUBMITTER: Wen Liu

PROVIDER: PXD066149 | iProX | Mon Jul 14 00:00:00 BST 2025

REPOSITORIES: iProX

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