Proteomics

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Multi-omics Analysis Reveals Age- Associated Molecular Mechanisms in SARS-CoV-2 and Influenza Virus Infection


ABSTRACT: To elucidate the clinical manifestations of SARS-CoV-2 and influenza virus infection across different age groups, C57BL/6N mice (n = 3/group) were inoculated with 4×104 tissue culture infective dose (TCID50) of SARS-CoV-2 Beta variant (B.1.351) and influenza virus through the intranasal route. The blank untreated control groups of the young group (pyp), adult-aged group (pmp) and elderly group (pop) received an equal amount of sterile phosphate-buffered saline (PBS) through the nasal route. Four days following infection, the animals were euthanized and their lung tissues were harvested for the purposose of phosphoproteomics and proteomics analysis analyses

ORGANISM(S): Mus Musculus

SUBMITTER: Juntao Yang  

PROVIDER: PXD066197 | iProX | Wed Jul 16 00:00:00 BST 2025

REPOSITORIES: iProX

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