GPX3 improves endometrial receptivity by inhibiting ferroptosis via Nrf2/GPX4 pathway in sows

ABSTRACT: Obesity is a vital inducement of reproductive disorders during early pregnancy in mammal. However, the effect and molecular mechanism of attenuating endometrial receptivity under obesity remain largely unknown. Here, we identified that GPX3 as a potential target for improving endometrial receptivity by integrating analysis of metabolomics and transcriptomics of uterine tissues in obese and normal sows.

ORGANISM(S): Sus Scrofa Domesticus

SUBMITTER: Weijun Pang  

PROVIDER: PXD066372 | iProX | Tue Jul 22 00:00:00 BST 2025

REPOSITORIES: iProX