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Proteomic analysis of Emx1-G6PD CKO mouse cortex

ABSTRACT: To identify differentially expressed proteins in the cerebral cortex between control and Emx1-G6PD CKO mice

ORGANISM(S): Mus Musculus

SUBMITTER: Lei Zhang

PROVIDER: PXD066386 | iProX | Tue Jul 22 00:00:00 BST 2025

REPOSITORIES: iProX

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G6PD deficiency in brain induces schizophrenia-like behaviors and synaptic dysfunction.

Wang Yu-Bing YB Xie Pin-Xi PX Mei Wan-Ying WY Yong Yuan-Yuan YY Yu Xinren X Hu Ling L Chen Jia-Yin JY Sun Yu-Ling YL Zhao Xuan X Song Ning-Ning NN Ding Yu-Qiang YQ Zhang Lei L

Translational psychiatry 20251031 1

Schizophrenia is a severe mental disorder characterized by aberrant brain development, influenced by genetic and environmental factors, with an incompletely understood etiology. Glucose-6-phosphate dehydrogenase (G6PD), a critical enzyme in the pentose phosphate pathway (PPP), facilitates NADPH production for biosynthesis and redox homeostasis. Recent studies suggests that PPP inhibition and consequent oxidative stress contribute to schizophrenia pathogenesis. While clinical investigations have ...[more]

PMID: 41173820

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