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Identification of Plasma Biomarkers for Sudden Unexpected Death in Epilepsy through Integrated Proteomics and Metabolomics

ABSTRACT: Identification of Plasma Biomarkers for Sudden Unexpected Death in Epilepsy through Integrated Proteomics and Metabolomics

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Peng Zhang

PROVIDER: PXD066692 | iProX | Mon Jul 28 00:00:00 BST 2025

REPOSITORIES: iProX

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Identification of plasma biomarkers in a PTZ-induced Sudden Unexpected Death-like model through integrated proteomics and metabolomics methods.

Zheng Gaolin G Yang Xinyan X Chen Yinyu Y Zhang Peng P Nie Qianyun Q

Frontiers in medicine 20260309

<h4>Introduction</h4>Sudden Unexpected Death in Epilepsy (SUDEP) refers to the unexplained, sudden death of individuals with epilepsy, and its incidence is closely linked to the severity and duration of seizures. This study aimed to identify plasma biomarkers associated with SUDEP through a combined proteomics and metabolomics approach.<h4>Methods</h4>A PTZ-induced seizure-related sudden death (SUDEP-like) paradigm was established in Sprague-Dawley (SD) rats via intraperitoneal injection of pent ...[more]

PMID: 41877782

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