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Proteomics of mouse bone marrow MLL-AF9 leukemia cells treated with Lep or Allo-aca in combination with Arac

ABSTRACT: Leptin is enriched in bone marrow adipose tissue, but its impact on therapeutic response in acute myeloid leukemia (AML) remains incompletely elucidated. Here, we report that in MLL-AF9 mouse model, exogenous leptin significantly compromised the cytotoxicity of Ara-C, whereas a high-affinity leptin receptor antagonist, Allo-aca, restored chemosensitivity without altering basal leukemia growth, accompanied by marked alterations in mitochondria-associated proteins.

ORGANISM(S): Mus Musculus

SUBMITTER: Huifang Huang

PROVIDER: PXD066693 | iProX | Mon Jul 28 00:00:00 BST 2025

REPOSITORIES: iProX

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