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Non-modified Molecules Strategy Enable Proteome-Wide Mapping of Catechol Derivatives Interactome

ABSTRACT: Here, we presented a modification-free strategy termed oxidative addition-boronate affinity enrichment (OABA), that leverages catechol oxidation to ortho-quinones for covalent capture of nucleophilic protein residues, followed by chemoselective enrichment via boronate affin-ity. This redox-enabled approach preserves native structure-activity relationships while enabling direct mapping of catechol-protein interactomes.

ORGANISM(S): Homo Sapiens

SUBMITTER: Lihua Zhang

PROVIDER: PXD067518 | iProX | Sat Aug 16 00:00:00 BST 2025

REPOSITORIES: iProX

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