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A Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract

ABSTRACT: A Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract

ORGANISM(S): Mus Musculus

SUBMITTER: Dezhi Kong

PROVIDER: PXD067684 | iProX | Mon Aug 25 00:00:00 BST 2025

REPOSITORIES: iProX

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A multi-omics comparison unveils convergent and divergent antidepressant mechanisms of fluoxetine and St. John's wort extract.

Zhang Jiale J Cai Yuhang Y Zhang Panpan P Hao Xurui X Guo Bowen B Zhang Wanning W Wu Yiying Y Sun Jiawen J Xu Xiang X Li Wanting W Zhang Bowen B Zhang Shuai S Zhang Wei W Kong Dezhi D

Journal of proteomics 20260306

Fluoxetine (Flx), a selective serotonin reuptake inhibitor, and St. John's Wort extract (SJW), a herbal remedy, are common treatments for depression. However, a comprehensive comparison of their molecular mechanisms remains elusive. This study aimed to systematically elucidate and compare their therapeutic actions using an integrated proteomics and metabolomics approach. Behavioral and pharmacological effects of both treatments were assessed through behavioral tests. Proteomics and metabolomics ...[more]

PMID: 41796893

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