FAM135B deficiency inhibits cytotoxic T cell activity in triple-negative breast cancer by blocking the IFI16-dependent STING pathway

ABSTRACT: FAM135B interacts with IFI16, inhibiting its ubiquitination and proteasomal degradation by competitively blocking its binding to the E3 ligase TRIM21, thereby initiating the IFI16-dependent STING signaling, ultimately leading to increased cytotoxic T cell activity.

ORGANISM(S): Homo Sapiens

SUBMITTER: Guangyu Yao  

PROVIDER: PXD068216 | iProX | Tue Sep 09 00:00:00 BST 2025

REPOSITORIES: iProX