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Dual-Omics Mapping of Tinnitus Phenotype Transition in Noise-Exposed Auditory Cortex-1

ABSTRACT: This study resolves a critical paradox: why noise-induced hearing loss (NIHL) does not universally progress to tinnitus. Through integrated proteomics and phosphoproteomics of auditory cortex tissue, we establish that tinnitus pathogenesis is driven by phosphorylation-mediated network dysregulation, fundamentally distinct from NIHL’s transcriptional-level changes.

ORGANISM(S): Mus Musculus

SUBMITTER: Fangyuan Wang

PROVIDER: PXD068358 | iProX | Sun Sep 14 00:00:00 BST 2025

REPOSITORIES: iProX

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