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Interactome of FLAG-STING in HCT116 cell line with or without P. gingivalis infection

ABSTRACT: The project aims to identify STING interactome that affected by P. gingivalis infection in HCT116 cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: Fuping Wen

PROVIDER: PXD068516 | iProX | Thu Sep 18 00:00:00 GMT+01:00 2025

REPOSITORIES: iProX

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Multiomics profiling reveals that <i>P. gingivalis</i>-induced extracellular vesicle reprogramming promotes immune evasion in colorectal cancer through autophagy-mediated STING degradation.

Zhang Xu X Huang Jieying J Shang Guangwei G Lu Yang Y Liu Haixia H Zhang Yiming Y Wen Fuping F Xu Yuanzhi Y

Frontiers in cellular and infection microbiology 20251015

<h4>Objective</h4><i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) infection is a recognized pathogenic factor in colorectal cancer (CRC), and extracellular vesicles (EVs) are key mediators within the tumor microenvironment. However, the molecular composition of large extracellular vesicles (lEVs) derived from <i>P. gingivalis</i>-infected cancer cells remains poorly characterized. This study aimed to comprehensively define the molecular cargo alterations in lEVs secreted by CRC cells in r ...[more]

PMID: 41170290

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