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The Roles of PFOA and PFOS on Human Sperm Capacitation

ABSTRACT: PFOS and PFOA are persistent organic pollutants known to impair human reproduction, but their effects and molecular mechanisms on human sperm remain unclear. Here, we conducted comprehensive proteomic and phosphoproteomic profiling of human sperm exposed to PFOS and PFOA during capacitation to provide systematic insights.

ORGANISM(S): Homo Sapiens

SUBMITTER: Peibei Sun

PROVIDER: PXD068914 | iProX | Sun Sep 28 00:00:00 BST 2025

REPOSITORIES: iProX

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PFOA and PFOS impair human sperm capacitation by inducing mitochondrial-mediated apoptosis and ferroptosis.

Gao Linmei L Pan Nanxu N Xu Wenting W Li Guoqiang G Li Kun K Shi Jing J Sun Peibei P

Ecotoxicology and environmental safety 20260115

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), two predominant per- and polyfluoroalkyl substances, are ubiquitous environmental contaminants that have been implicated in male infertility. However, the effects and underlying mechanisms of these compounds during human sperm capacitation remain unclear. In this study, human spermatozoa were exposed to PFOA and PFOS during capacitation. Acrosome reaction and sperm viability were assessed by flow cytometry. Sperm motility and hy ...[more]

PMID: 41544354

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