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Study on the protective effects and molecular mechanisms of L-sodium lactate in mouse colitis

ABSTRACT: The therapeutic potential of L-sodium lactate was investigated in a dextran sodium sulfate (DSS)-induced colitis model. Treatment with L-sodium lactate significantly mitigated disease severity, as evidenced by reduced colon shortening (P < 0.05) and elevated levels of the anti-inflammatory cytokine IL-10 (P < 0.05). Tandem mass tag (TMT)-based proteomic profiling revealed dual mechanisms, including the upregulation of cell cycle- and proliferation-associated proteins (PCNA, SMC, eEF2K) and the downregulation of immune-related proteins (immunoglobulin variants, Granzyme A). In vitro, 10 μM L-sodium lactate promoted the proliferation and migration of colorectal cancer cells （MC38/HCT116）（P < 0.05），accompanied by increased expression of c-Myc and PCNA. Collectively, these findings identify L-sodium lactate as a key metabolite that enhances mucosal repair while suppressing inflammation.

ORGANISM(S): Mus Musculus

SUBMITTER: Pan Huang

PROVIDER: PXD069291 | iProX | Fri Oct 10 00:00:00 GMT+01:00 2025

REPOSITORIES: iProX

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