Dataset Information

An exploratory study of urinary proteome in trigeminal neuralgia

ABSTRACT: Urine proteomics technology was used to analyze 11 healthy individuals (7 males, 4 females; age range 32–71, mean 51, standard deviation 11) and 10 patients with trigeminal neuralgia (TN) (6 males, 4 females; age range 38–68, mean 54, standard deviation 10)

ORGANISM(S): Homo Sapiens

SUBMITTER: Yongtong Cao

PROVIDER: PXD069864 | iProX | Fri Oct 24 00:00:00 BST 2025

REPOSITORIES: iProX

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An exploratory study of urinary proteome in trigeminal neuralgia.

Wei Lilong L Wang Haitong H Zhou Yun Y Wu Jianqiang J Cao Yongtong Y Zhan Yuliang Y Gao Youhe Y

Frontiers in molecular biosciences 20251030

<h4>Background</h4>Trigeminal neuralgia (TN) is a neurological disorder characterized by severe pain and a complex pathogenesis. This condition seriously affects patients' quality of life. The analysis of urinary proteomics has shown great potential in disease research.<h4>Objective</h4>The aim of this study is to explore the diagnostic and therapeutic value of urine proteomics in TN.<h4>Method</h4>The urine of 10 cases of TN and 11 healthy individuals were studied using liquid chromatography-ma ...[more]

PMID: 41244708

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Project description:The exact role of epigenetics in the pathogenesis of severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) is unclear. Herein we have hypothesized that viral micro RNAs (miRNAs) may modulate host cellular and immune responses which may lead to varied clinical presentations. Using bioinformatics tools, we have first predicted putative miRNAs in the genotype of the SARS-CoV-2 and their potential gene targets. Thereafter, quantification of mRNA of key genes regulating inflammation, coagulation, neuropsychiatric functions, fibrosis and glucose metabolism was evaluated in the peripheral blood mononuclear cells and bone marrow of patients suffering from different severities of SARS-CoV-2 infection. Key genes regulating innate immunity, lymphopoiesis, T-cell and B-cell development, cytokine storm, coagulation pathways, fibrosis, neuropsychiatric manifestations, glucose metabolism, and olfaction were significantly downregulated in severe infection when compared with mild infection. Downregulated genes mRNA recovered to normal/near normal levels on recovery from infection. SARS-CoV-2 miRNAs appear promising players in the pathogenesis of COVID-19. Strategies silencing these miRNAs may be explored further as potential therapeutic targets. Patients with severe illness were defined as: respiratory rate ≥30 per min or SpO2 <90% in ambient air, or acute respiratory distress syndrome or septic shock and those with mild illness as: patients with any of the symptoms like fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, loss of taste and smell, but no dyspnea, or abnormal chest imaging. There were 4 severe SARS CoV-2 patients, Median age 57.5 years (Range 50-72 years), all males, median disease duration 7.5 days, duration of hospital stay 38 days with outcome as 3 deaths and one Post covid lung fibrosis. All 4 mild cases had median age 55.5 years (range 42-0 years), 3 males and one female, mean disease duration 2.8 days, mean duration of hospitalization 14.5 days and all recovered. Median age of all 4 recovered cases was 59 years (range 43-77 years), 3 males and one female, mean disease duration of 6 days, mean disease duration of 22 days and all recovered. There were 4 healthy subjects with median age 50 years (range 42-54 years) and there were 3 males and one female.

Dataset Information

An exploratory study of urinary proteome in trigeminal neuralgia

Publications

An exploratory study of urinary proteome in trigeminal neuralgia.

Similar Datasets

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