Proteome of TGF-β1-Induced Human Primary Mesothelial Cells treated with and without BCAT1/2 inhibitor

ABSTRACT: Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, primarily driven by TGF-β1-induced mesothelial-to-mesenchymal transition. BCAT1 and BCAT2 are key enzymes in branched-chain amino acid metabolism, yet their specific roles and mechanisms in peritoneal fibrosis remain unclear. This project aims to elucidate the mechanism by which inhibition of BCAT1 and BCAT2 alleviates TGF-β1-induced peritoneal fibrosis. We seek to identify the key proteomic changes and signaling pathways that are reversed by BCAT1/2 inhibition.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xuemei Zhang  

PROVIDER: PXD069866 | iProX | Thu Oct 23 00:00:00 GMT+01:00 2025

REPOSITORIES: iProX