Proteomics

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Proteomic Analysis of the impact of uric acid pretreatment on APAP-treated mouse primary hepatocytes


ABSTRACT: This study investigates the effect of uric acid (UA) pretreatment on protein expression profiles in acetaminophen (APAP)-induced hepatotoxicity. Primary mouse hepatocytes were divided into two groups: APAP and UA+APAP. Cells in the UA+APAP group were pretreated with 400 μM UA for 2 hours, followed by 5 mM APAP treatment for 6 hours. After treatment, proteins were extracted and analyzed using LC-MS/MS-based proteomics.

ORGANISM(S): Mus Musculus

SUBMITTER: Shenhai Gong  

PROVIDER: PXD070057 | iProX | Wed Oct 29 00:00:00 GMT 2025

REPOSITORIES: iProX

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