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Multilineage-differentiating stress-enduring cells alleviate neuropathic pain in mice by secreting TGF-β and IL-10

ABSTRACT: Muse cells can mitigate neuroinflammation and produce analgesic effects via the modulation of TGF-β and IL-10

ORGANISM(S): Homo Sapiens

SUBMITTER: Gang Chen

PROVIDER: PXD070082 | iProX | Thu Oct 30 00:00:00 GMT 2025

REPOSITORIES: iProX

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Multilineage differentiating stress-enduring cells alleviate neuropathic pain in mice through TGF-β and IL-10-dependent anti-inflammatory signaling.

Zhao Yayu Y Fei Ying Y Cai Yunyun Y Wei Zhongya Z Chen Ying Y Ji Yuhua Y Chen Xue X Chen Gang G

The Journal of biological chemistry 20260206 3

Neuropathic pain is a chronic condition characterized by damage to and dysfunction of the peripheral or central nervous system. There are currently no effective treatment options available for neuropathic pain, and existing drugs often provide only temporary relief with potential side effects. Multilineage-differentiating stress-enduring (Muse) cells are characterized by high expansion potential, a stable phenotype and strong immunosuppression. These properties make them attractive candidates fo ...[more]

PMID: 41655691

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