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PCT-assisted DIA Proteomics Unveils Molecular Changes in Kidney Tissues of Patients with Minor Glomerular Abnormalities

ABSTRACT: Our study pioneers a systematic comparison of DNT and MGA proteomes using cutting-edge analytical workflows. Freshly obtained kidney tissues (acquired via puncture or surgery) underwent pressure cycling technology (PCT)-assisted lysis15, 16. The extracted proteins then underwent proteolysis using a modified filter-aided sample preparation (FASP) and data independent acquisition (DIA) MS. This approach not only establishes rigorous methodological benchmarks for control selection but also maps MGA-specific protein networks, potentially revealing actionable biomarkers or therapeutic targets. By integrating advanced proteomic technologies with clinical nephrology, this work may redefine diagnostic paradigms and therapeutic strategies for MGAs.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yong Zhang

PROVIDER: PXD070517 | iProX | Mon Nov 10 00:00:00 GMT 2025

REPOSITORIES: iProX

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