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Computational and Experimental Verification of Cabozantinib to Inhibit DNA Damage Repair in Liver Cancer

ABSTRACT: The proteomics study of cabozantinib-treated hepatocellular carcinoma cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: Liping Liu

PROVIDER: PXD070703 | iProX | Thu Nov 13 00:00:00 GMT 2025

REPOSITORIES: iProX

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Computational and Experimental Verification of Cabozantinib Targeting DDX11 to Inhibit DNA Damage Repair in Liver Cancer.

Li Lianhai L Huang Zhenhui Z Liu Zhensen Z Zhong Juxian J Li Deliang D Liu Liping L

ACS omega 20260123 5

Phosphorylation of serine residues within SQ/TQ motifs, particularly Ser237 of the ATP-dependent DNA helicase DDX11, by ataxia telangiectasia mutated (ATM) kinase plays a key role in activating the DNA damage response (DDR) in liver cancer. To disrupt this signaling pathway, we applied a computationally guided drug repurposing approach to identify FDA-approved compounds capable of targeting critical DDX11 residues. A library of 2367 drugs was screened using a structure-based, site-specific docki ...[more]

PMID: 41696275

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