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Deubiquitinase OTULIN dampens RIG-I dependent type I IFN signaling by removing the linear ubiquitination from TRAF6

ABSTRACT: In this study, we observed a global increase in intracellular linear ubiquitination upon RNA viral infection, suggesting that linear ubiquitination may be a prerequisite for the initiation of antiviral innate immunity. Furthermore, using a combination of various cell lines and in vivo experiments, we identified OTULIN as a critical negative regulator of RNA virus-induced type I IFN signaling by specifically removing linear ubiquitin chains from TRAF6.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xiaoyun Liu

PROVIDER: PXD070809 | iProX | Sat Nov 15 00:00:00 GMT 2025

REPOSITORIES: iProX

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