SIRT5 ameliorates cardiac fibrosis via PCK2 de-succinylation–mediated metabolic reprogramming in cardiac fibroblasts
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ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Yangxin Chen
PROVIDER: PXD070811 | iProX | Sat Nov 15 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
SIRT5 Ameliorates Cardiac Fibrosis via PCK2 Desuccinylation-Mediated Metabolic Reprogramming in Cardiac Fibroblasts.
Wu Maoxiong M Tan Jing J Zhou Weibin W Zhang Zenghui Z Gao Qingyuan Q Cai Yangwei Y Liao Guanghong G Cao Zhengyu Z Zeng Chuanrui C Zhang Yi Y Chen Zhiteng Z Qiu Qiong Q Liu Zhaoyu Z Wang Jingfeng J Zhang Haifeng H Chen Yangxin Y
Circulation 20260423
<h4>Background</h4>SIRT5 (sirtuin 5) is a member of the sirtuin family known to regulate cardiac metabolism, aging, and function. However, its role in cardiac fibroblast (CFB) metabolism, activation, and fibrosis remains elusive.<h4>Methods</h4>Expression changes of SIRT5 in CFBs from cardiac tissue of human and mouse with heart failure were determined. The functional role of SIRT5 in cardiac fibrosis was evaluated through CFB-specific knockout and overexpression of <i>Sirt5</i> in mice. The inv ...[more]
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