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PP2Acα regulates cerebellar development via phosphorylation-dependent neuronal programs

ABSTRACT: The proteomics and phosphorylation proteomics of PP2Acα regulates cerebellar development via phosphorylation-dependent neuronal programs.

ORGANISM(S): Mus Musculus

SUBMITTER: Yamei Niu

PROVIDER: PXD071414 | iProX | Fri Nov 28 00:00:00 GMT 2025

REPOSITORIES: iProX

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PP2Acα regulates cerebellar development via phosphorylation-dependent neuronal programs.

Li Yifan Y Ding Jing J Liu Simeng S Wu Qiao Q Fu Yujie Y Li Qing Q Lv An A Liu Chunying C Tong Wei-Min WM Niu Yamei Y

iScience 20251205 1

Cerebellar development requires precise control of phosphorylation, yet the contribution of protein phosphatases remains poorly understood. Here, we investigated the function of protein phosphatase 2A catalytic subunit alpha (PP2Acα) in cerebellar granule neurons. Conditional deletion of <i>Ppp2ca</i> using <i>Atoh1-Cre</i> mice resulted in impaired motor coordination and cognitive performance, reflecting disrupted cerebellar development. Histological analyses revealed abnormal granule neuron pr ...[more]

PMID: 41509924

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