Proteomics and β-Hydroxybutyrylation Profiling in Starvation-Induced Skeletal Muscle
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Yang Xiang
PROVIDER: PXD071518 | iProX | Wed Dec 03 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
Comprehensive Proteomics and β-Hydroxybutyrylation Profiling in Starvation-Induced Gastrocnemius Muscle Remodeling.
Cui Leilei L Huang Chunping C Su Yu Y Xu Shiqi S Zha Liang L Zhao Qiuyuan Q Quan Wu W Lan Xinqiang X Xiang Yang Y Wang Qiquan Q
Biology 20260206 3
Starvation elicits profound metabolic adaptations in skeletal muscle, enabling survival during nutrient scarcity. While global proteomic changes underpinning muscle atrophy have been studied, the role of lysine β-hydroxybutyrylation (Kbhb), a novel metabolite-derived post-translational modification linked to ketone metabolism, remains largely unexplored. In this study, we subjected mice to 72 h of food deprivation and performed integrative quantitative proteomics and Kbhb-modified peptide profil ...[more]
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