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Xylitol ameliorates ASD-like behavior in Chd8+/− mice via modulations of the gut microbiome, neurotransmitters, and dendritic spine morphology

ABSTRACT: This dataset contains multi-omics and neurobiological data from a study demonstrating that xylitol ameliorates ASD-like phenotypes in mutant mice via the gut-brain axis. It includes gut microbiota (16S) and targeted metabolomics data showing restoration of microbial and neurotransmitter balance, alongside data on improved social behavior, synaptic morphology, and neuronal activity.

ORGANISM(S): Mus Musculus

SUBMITTER: Meng Sun

PROVIDER: PXD071711 | iProX | Mon Dec 08 00:00:00 GMT 2025

REPOSITORIES: iProX

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Xylitol ameliorates ASD-like behavior in Chd8+/- mice via modulations of the gut microbiome, neurotransmitters, and dendritic spine morphology.

Sun Meng M Wang Xin X Zhang Qian Q Wang Ziyi Z Luo Jianhong J Xu Junyu J Li Xiaoqiong X

Food & function 20260803 15

Autism spectrum disorder (ASD) is a neurodevelopmental condition with complex etiology involving gut-brain axis interactions. It remains elusive how prebiotics modulate this axis to alleviate ASD symptoms. This study aimed to investigate whether xylitol, a potential prebiotic, improves behavioral and neural deficits in Chd8+/- mice, a genetic model of ASD, and to explore the associated roles of the gut microbiome, neurotransmitters and synaptic morphology in these effects. We f ...[more]

PMID: 42300458

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