SP3-PELSA: A Rapid and Sensitive Approach for Studying Protein-Ligand Interaction with Limited Samples

ABSTRACT: SP3-PELSA, a modified peptide-centric local stability assay integrated with SP3 sample preparation, enables fivefold faster processing, enhanced peptide recovery (especially for hydrophobic peptides and low-amount samples), and superior performance in drug target discovery, holding great potential for large-scale applications and studies on membrane proteins using scarce clinical samples.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xumin Zhang  

PROVIDER: PXD071732 | iProX | Wed Dec 10 00:00:00 GMT 2025

REPOSITORIES: iProX